Sickle cell anaemia results from:
Correct answer: C. Single amino acid substitution in the haemoglobin molecule
- A. Reduction in oxygen-carrying capacity of haemoglobin
- B. Linkage between the polypeptide chains in the haemoglobin molecule
- C. Single amino acid substitution in the haemoglobin molecule
- D. Viral infections of RNA viruses
Explanation
Sickle cell anemia is caused by a genetic mutation in the HBB gene, which provides instructions for making hemoglobin, the protein in red blood cells that carries oxygen throughout the body. This mutation leads to the production of an abnormal form of hemoglobin called hemoglobin S (HbS).
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About Chromosomes
Chromosomes are DNA-protein structures that carry genes and become visible during cell division. Coverage includes chromatin, centromeres, sister chromatids, homologous chromosomes, chromosome number, and the distinction between diploid and haploid cells, with links to DNA replication, mitosis and meiosis.
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