Scientists use a process called Fluorescent In-Situ Hybridization, or FISH, to study genetic disorders in humans. FISH is a technique that uses spectrographic analysis to determine the presence or absence, as well as the relative abundance, of genetic material in human cells. To use FISH, scientists apply fluorescently-labeled bits of DNA of a known colour, called probes, to samples of test DNA. These probes anneal to the sample DNA, and scientists can read the colours that result using laboratory equipment. One common use of FISH is to determine the presence of extra DNA in conditions of aneuploidy, a state in which a human cell has an abnormal number of chromosomes. Chromosomes are collections of DNA, the totality of which makes up a cell's genome. Another typical use is in the study of cancer cells, where scientists use FISH labels to ascertain if genes have moved inappropriately in a cell's genome. Using red fluorescent tags, scientists label probe DNA for a gene known to be expressed more heavily in cancer cells than normal cells. They then label a probe for an immediately adjacent DNA sequence with a green fluorescent tag. Both probes are then added to three dishes, shown below. In dish 1 human bladder cells are incubated with the probes, in dish 2 human epithelial cells are incubated, and in dish 3 known non-cancerous cells are used. The relative luminescence observed in regions of interest in all dishes is shown below.Aneuploidy can also affect some fertilized zygotes after abnormalities in fertilization or gametogenesis. Aneuploid zygotes are typically spontaneously aborted before a pregnancy comes to term. A normal zygote binds to uterine endometrium while it is at its thickest, supported by progesterone secretion from which of the following?
Correct answer: D. Corpus luteum
- A. Graafian follicle
- B. Hypothalamus
- C. Posterior pituitary
- D. Corpus luteum
Explanation
The corpus luteum forms after ovulation, when a pregnancy would be most expected. The corpus luteum secretes progesterone, which maintains the endometrium for potential implantation.
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About Chemical Coordination and Hormones
Chemical coordination uses hormones released by endocrine glands and carried in blood to specific target cells. Coverage includes the pituitary, thyroid, pancreas, adrenal glands, ovaries and testes, feedback control, and the contrast between slower, longer-lasting hormonal responses and rapid nervous coordination.
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