Leukocytoclastic vasculitis is characterized microscopically by:
Correct answer: C. Fibrinoid change with nuclear debris in vessel walls
- A. Thrombus formation without vessel injury
- B. Smooth muscle hypertrophy without inflammation
- C. Fibrinoid change with nuclear debris in vessel walls
- D. Amyloid deposition around arterial nerves
Explanation
Leukocytoclastic vasculitis shows inflammation of small vessels with fragmented leukocyte nuclei, often accompanied by fibrinoid necrosis. The nuclear debris results from destruction of infiltrating neutrophils and is a major diagnostic clue.
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Covers the causes and mechanisms of disease, cellular injury, inflammation, healing, circulatory disturbances, neoplasia and disorders of major organs. It also includes gross and microscopic pathological changes, specimen interpretation and the distinction between aetiology, pathogenesis, clinical signs and lesions.
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