Isoniazid is an antibiotic drug prescribed by physicians to treat tuberculosis (TB). It works by inhibiting the activity of RNA polymerase in the pathogenic bacterial cell. Which of the following process(es) will be directly affected in the bacterial cell by this inhibition?I. DNA replication.II. Transcription.III. ATP synthesis.
Correct answer: B. II only
- A. I only
- B. II only
- C. I and III
- D. II and III
Explanation
The correct answer is Option B: II only. RNA polymerase is an enzyme that is critical for the process of transcription, where RNA is synthesized from a DNA template. Inhibition of RNA polymerase directly affects transcription. DNA replication (Option I) involves different enzymes such as DNA polymerase and is not directly impacted by the inhibition of RNA polymerase. ATP synthesis (Option III) occurs in the cellular processes of respiration and is not directly related to RNA polymerase activity.
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About Ribonucleic Acid (RNA)
Ribonucleic acid is generally a single-stranded nucleic acid containing ribose and uracil instead of thymine. Coverage includes mRNA, tRNA and rRNA, complementary base pairing, transcription and translation, and the differences between RNA and DNA in structure, location and biological function.
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