In X linked recessive inheritance, the criss cross pattern means that a trait typically passes from

  • A. father to son directly
  • B. mother to daughter only
  • C. father to every one of his sons
  • D. an affected man to his grandsons through his carrier daughters

Explanation

An affected father gives his X, and therefore the allele, to all of his daughters, who become carriers, and half of their sons then inherit it, so the trait reappears in the grandsons. A father can never pass an X linked allele to a son, because a son receives his Y from the father and his X from the mother. That impossibility is the quickest way to rule out X linkage in a pedigree.

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