In Down's syndrome, which one of the following pair of chromosome fails to segregate?
Correct answer: C. 21
- A. 7
- B. 18
- C. 21
- D. 19
Explanation
Down's syndrome is a genetic condition in which the 21st chromosome fails to segregate, leading to physical and mental developmental delay and disabilities. Down syndrome symptoms include distinctive physical features like upward slanting eyes, a flattened face, a short neck, and small ears, hands, and feet, along with low muscle tone and loose joints. Individuals also experience intellectual and developmental delays, and may face other health issues such as heart problems, hearing loss, gastrointestinal issues, and vision problems.
This question appeared on the UHS MDCAT 2012 paper, which you can sit online with every answer explained.
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About Chromosomes
Chromosomes are DNA-protein structures that carry genes and become visible during cell division. Coverage includes chromatin, centromeres, sister chromatids, homologous chromosomes, chromosome number, and the distinction between diploid and haploid cells, with links to DNA replication, mitosis and meiosis.
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