Heavy metal ions such as mercury and lead are poisonous partly because they

Correct answer: D. bind to sulphur containing groups in enzymes and denature them irreversibly

  • A. increase enzyme activity uncontrollably
  • B. are converted into proteins by the body
  • C. supply too much energy to the cell
  • D. bind to sulphur containing groups in enzymes and denature them irreversibly

Explanation

These ions attack the sulphydryl side chains of cysteine, breaking disulphide bridges and destroying the tertiary structure, so the affected enzymes lose all activity permanently. Because the damage cannot be reversed by removing the metal, the effect is poisoning rather than simple inhibition. This is also why drinking milk or egg white gives some first aid benefit, as those proteins bind the metal first.

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About Enzymes as Biocatalysts

Enzymes are protein or RNA biocatalysts that lower activation energy without being consumed, and their active sites bind specific substrates. The topic covers the lock and key and induced fit models, effects of temperature, pH and substrate concentration, cofactors, enzyme specificity, and competitive versus non-competitive inhibition.

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