Haemophilia affects males than females because of:
Correct answer: A. X linked recessive
- A. X linked recessive
- B. X linked dominant
- C. Dominant autosomes
- D. Y linked inheritance
Explanation
Haemophilia is an X-linked recessive disorder, which means it is more commonly seen in males than females. This is because the gene responsible for haemophilia is located on the X chromosome. Males have one X chromosome and one Y chromosome, while females have two X chromosomes. If a male inherits the faulty gene on his X chromosome, he will have haemophilia because he does not have another X chromosome to compensate for the faulty gene. Females, on the other hand, have two X chromosomes, so even if one X chromosome carries the faulty gene, the other X chromosome can often compensate for it. That's why haemophilia is more prevalent in males.
This question appeared on the KMU Centralized Admission Test 2020 paper, which you can sit online with every answer explained.
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About X-linked Recessive Inheritance
X-linked recessive inheritance involves genes on the X chromosome, so males express a recessive allele with no corresponding allele on their single X chromosome, while females may be carriers. Pedigrees cover haemophilia and red-green colour blindness, including carrier mothers, affected sons and the absence of father-to-son transmission.
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