Formation of acetyl-CoA from pyruvic acid needs:

Correct answer: C. Multi-enzyme complex

  • A. A single enzyme
  • B. Two enzymes
  • C. Multi-enzyme complex
  • D. No enzyme

Explanation

The conversion of pyruvic acid to acetyl CoA is a crucial step in cellular respiration and is catalyzed by the pyruvate dehydrogenase complex, a multi-enzyme system. This complex includes several enzymes, such as pyruvate dehydrogenase, dihydrolipoamide acetyltransferase, and dihydrolipoamide dehydrogenase, along with multiple cofactors. The complexity of this system allows for efficient transformation of pyruvic acid into acetyl-CoA, a key molecule for entry into the citric acid cycle. The incorrect options suggest fewer enzymes or no enzymes at all, which would be inadequate for this biochemical process.

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Cellular respiration explains how cells release energy from glucose through glycolysis, the link reaction, Krebs cycle and electron transport chain. It includes ATP production, substrate-level and oxidative phosphorylation, aerobic versus anaerobic respiration, and the roles of mitochondria, oxygen and fermentation in energy transfer.

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