Following events are associated with a lysosomal disorder called Tay Sach's disease. Arrange them in a specific sequence with respect to their occurrence: i. Mental retardation ii. Inheritance of abnormal gene iii. Accumulation of lipids in brain cells iv. Lack of catabolism of lipids v. Absence of an enzyme
Correct answer: D. ii, v, iv, iii, i
- A. i, ii, iii, iv, v
- B. v, iv, iii, ii, i
- C. ii, iv, i, iii, v
- D. ii, v, iv, iii, i
Explanation
When someone inherits an abnormal gene associated with the synthesis of the enzyme required for the catabolism of lipids, the person will lack such enzymes. As a consequence, there willbe no catabolism of lipids, and lipids will be accumulated in the brain cells. It will result in mental retardation.
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