Anaphase-promoting complex (APC) is a protein degradation machinery necessary for the proper mitosis of an animal cell. If APC is defective in a human cell, which of the following is expected to occur?
Correct answer: B. Chromosomes will not segregate
- A. Chromosomes will be fragmented
- B. Chromosomes will not segregate
- C. Recombination of chromosome arms will occur
- D. Chromosomes will not condense
Explanation
During anaphase in mitosis, sister chromatids segregate at opposite poles. Therefore, a defective APC will affect chromosome segregation.A defective APC can have detrimental consequences for the proper functioning of mitosis and the cell cycle. It can lead to a range of issues, including genomic instability, aneuploidy, cancer development, and cell death, ultimately affecting the overall health and functionality of an organism. The specific effects may vary depending on the extent and nature of the APC defect.
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