All are true about metformin except_____________?
Correct answer: D. Used in decompensated heart failure
- A. Inhibits cellular respiration in mitochondria
- B. Excreted unchanged in urine
- C. Reduce hepatic glucose production
- D. Used in decompensated heart failure
Explanation
Metformin reduces hepatic glucose production and is excreted unchanged by the kidneys, partly by inhibiting mitochondrial complex I. It is contraindicated in decompensated heart failure because tissue hypoxia increases the risk of lactic acidosis.
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