A weakly basic drug is more likely to become ionized and trapped in which environment?
Correct answer: A. Acidic urine
- A. Acidic urine
- B. Alkaline urine
- C. Neutral plasma
- D. Alkaline bile
Explanation
Weak bases become more protonated and ionized in acidic urine, which reduces passive tubular reabsorption and may increase excretion. This pH-dependent trapping is different from protein binding in plasma.
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About Veterinary Pharmacology
Covers how drugs act in animals, including pharmacokinetics, pharmacodynamics, routes of administration, dosage forms, adverse effects and drug interactions. Major groups include antimicrobials, antiparasitics, analgesics, anaesthetics, anti-inflammatory drugs, hormones and cardiovascular medicines, with attention to withdrawal periods and species differences.
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