A patient takes an oral drug that is extensively metabolised by the liver before reaching the systemic circulation. Which pharmacokinetic process is involved?
Correct answer: A. First-pass metabolism
- A. First-pass metabolism
- B. Renal tubular secretion
- C. Plasma protein binding
- D. Glomerular filtration
Explanation
First-pass metabolism occurs when an orally absorbed drug passes through the intestinal wall and liver before entering the general circulation. Glomerular filtration and tubular secretion help excrete drugs, while protein binding affects distribution.
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About Principles of Pharmacology
Pharmacology examines drug sources, names, dosage forms, mechanisms of action, absorption, distribution, metabolism and excretion. Questions cover pharmacokinetics versus pharmacodynamics, therapeutic effects, adverse reactions, contraindications, drug interactions, tolerance, dependence and the safety responsibilities of the nurse.
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