A loading dose is primarily determined by the desired plasma concentration and which pharmacokinetic parameter?
Correct answer: D. Volume of distribution
- A. Urine flow rate
- B. Renal clearance
- C. Elimination half-life alone
- D. Volume of distribution
Explanation
Loading dose is based mainly on the target concentration and volume of distribution, with adjustment for bioavailability when the route is not intravenous. Clearance mainly determines the maintenance dose or dosing interval.
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Covers how drugs act in animals, including pharmacokinetics, pharmacodynamics, routes of administration, dosage forms, adverse effects and drug interactions. Major groups include antimicrobials, antiparasitics, analgesics, anaesthetics, anti-inflammatory drugs, hormones and cardiovascular medicines, with attention to withdrawal periods and species differences.
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