Free Nucleophilic Substitution MCQs with Answers

65 Nucleophilic Substitution MCQs from Chemistry, each with the correct answer and a written explanation of why it is correct. Free and unlimited, with no account needed.

Nucleophilic substitution replaces a leaving group in an alkyl halide when an electron-rich nucleophile attacks the carbon atom. The topic compares SN1 and SN2 mechanisms, including reaction conditions, substrate structure, solvent effects, nucleophile strength, carbocation formation and stereochemical changes, and distinguishes substitution from elimination.

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65 questions · page 4 of 4

  • A. Secondary amine
  • B. Tertiary amine
  • C. Quaternary ammonium salt
  • D. Mixture of (a), (b) & (c)

Explanation: When primary amines are treated with alkyl halides, they undergo a series of nucleophilic substitution reactions.

Correct answer: Mixture of (a), (b) & (c)
  • A. C6 H5O
  • B. H-O-
  • C. NH3
  • D. C2 H5 O-

Explanation: Nucleophilicity increases as the density of negative charge increases. An anion is always a better nucleophile than a neutral molecule, so…

Correct answer: H-O-
  • A. Electrophile
  • B. Nucleophile
  • C. Lewis base
  • D. None

Explanation: An electron-deficient species is one that has a deficiency of electrons, making it "electron-seeking" or electron-loving.

Correct answer: Electrophile
  • A. Inversion only
  • B. Retention only
  • C. Equal inversion and retention
  • D. More inversion and retention

Explanation: In SN1 reactions, the formation of a planar carbocation allows for nucleophilic attack from either side, resulting in both inversion and…

Correct answer: More inversion and retention
  • A. H2O
  • B. AlCl3
  • C. BF3
  • D. Cl2

Explanation: A nucleophile is a species that donates a pair of electrons to form a covalent bond with an electrophile.

Correct answer: H2O