Within the RBC hypoxia stimulates glycolysis by which of the following regulating pathways ?
Correct answer: B. Hypoxia stimulates release of all glycolytic enzymes from Band 3 on RBC membrane
- A. Hypoxia stimulates pyruvate dehydrogenase by increased, 2, 3DPG
- B. Hypoxia stimulates release of all glycolytic enzymes from Band 3 on RBC membrane
- C. Hypoxia inhibits hexokinase
- D. Activation of the regulatory enzymes by high PH
Explanation
During hypoxia, deoxyhaemoglobin binds the cytoplasmic domain of band 3 and displaces glycolytic enzymes, increasing their access to the membrane and stimulating glycolysis. The other choices describe incorrect effects on pyruvate dehydrogenase, hexokinase or pH.
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