Which of the following statements regarding nitroglycerin is true ?
Correct answer: D. All of the above
- A. The effect is more pronounced in venous
- B. High membrane penetrability
- C. Poorly suited for oral administration
- D. All of the above
Explanation
Nitroglycerin is highly lipid-soluble and rapidly crosses membranes, but extensive first-pass metabolism makes it poorly suited to ordinary oral dosing. Its vasodilator effect is greater in veins, reducing venous return and cardiac preload, so all three statements are true.
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