Which of the following statements is not correct regarding warfarin_____________?
Correct answer: C. In a racemic mixture the R form is four times more active than the S form
- A. Transient hypercoagulability is seen
- B. Better avoided during pregnancy as it may causes skeletal deformity of the foetus
- C. In a racemic mixture the R form is four times more active than the S form
- D. The anticoagulant effect is seen only after 72 hours of administration
Explanation
Warfarin's S-enantiomer is more potent than its R-enantiomer, generally by about three- to fivefold, so the claim that R is four times more active is reversed. The delayed anticoagulant effect, early transient hypercoagulability, and fetal skeletal abnormalities are recognized features of warfarin therapy.
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