Which of the following statements about Azoles is false ?
Correct answer: D. They affect the metabolism of drugs such as cyclosporine necessitating an increasing in dosage
- A. They are fungistatic
- B. They are hepatotoxic
- C. Resistance to the drug is common
- D. They affect the metabolism of drugs such as cyclosporine necessitating an increasing in dosage
Explanation
Azoles inhibit fungal ergosterol synthesis and are usually fungistatic; hepatotoxicity and resistance are recognized problems. They inhibit hepatic CYP enzymes, increasing cyclosporine concentrations, so the cyclosporine dose generally needs to be reduced, not increased.
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