A patient is talking terfenadine for cold and comes for tooth extraction. What tablet you have given which makes him suffer from cardiac arrhythmia______________?
Correct answer: A. Erythromycin
- A. Erythromycin
- B. Doxycycline
- C. Penicillin
- D. Streptomycin
Explanation
Erythromycin inhibits CYP3A4 and reduces terfenadine metabolism, increasing its concentration and prolonging the QT interval, which may cause serious ventricular arrhythmias. Doxycycline, penicillin and streptomycin do not have this classic interaction.
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Practise Antimicrobial Agents
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