Which of the following is correct of the pyruvate dehydrogenase enzyme complex ?
Correct answer: C. Requires TPP as cofactor
- A. It is present in cytoplasm
- B. Catalyzes the conversion of pyruvate to oxaloacetate
- C. Requires TPP as cofactor
- D. Catalyzes a reversible reaction
Explanation
Pyruvate dehydrogenase is a mitochondrial complex that irreversibly converts pyruvate to acetyl-CoA, not oxaloacetate. Its E1 component requires thiamine pyrophosphate, making option c correct.
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