Which of the following diseases is characterized by the accumulation of lipids in the brain cells leading to mental retardation and even death?

Explanation

Tay-Sachs disease is a rare, inherited disorder that is caused by the accumulation of a fatty substance called GM2 ganglioside in the brain cells. This accumulation of GM2 ganglioside leads to the death of brain cells, which results in progressive neurological decline. Tay-Sachs disease is usually diagnosed in infants and young children. The first symptoms of the disease typically appear between 4 and 6 months of age. These symptoms can include:Vision problems: Infants with Tay-Sachs disease may develop nystagmus, which is a condition in which the eyes make involuntary movements. They may also develop cataracts, which are cloudy areas in the lens of the eye.Developmental delays: Infants with Tay-Sachs disease may have delayed development. They may not reach their developmental milestones on time, such as rolling over, sitting up, or walking.Seizures: Infants with Tay-Sachs disease may develop seizures.Behavioral changes: Infants with Tay-Sachs disease may become irritable and withdrawn. They may also have difficulty sleeping.