Which of the following changes could lead to loss of enzymatic function?
Correct answer: D. Increase in pH of the reaction
- A. Decrease in activation energy of the reaction
- B. Increase in enzyme concentration
- C. Change in overall enthalpy of the reaction
- D. Increase in pH of the reaction
Explanation
A. Decrease in activation energy of the reaction (Incorrect): This would enhance the reaction rate, but it won't cause loss of enzymatic function.B. Increase in enzyme concentration (Incorrect): Higher enzyme concentration can accelerate the reaction, but it won't lead to loss of enzymatic function.C. Change in overall enthalpy of the reaction (Incorrect): Enzymes facilitate reactions without altering the overall enthalpy, so changes in it won't cause loss of enzymatic function.D. (Correct) Enzymes are pH and temperature sensitive., and only function in optimal ranges of these conditions.
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About Enzymes
Enzymes are biological catalysts that lower activation energy without being consumed, and their specificity is explained by the lock and key and induced fit models. Work includes the effects of temperature, pH and substrate concentration on reaction rate, plus competitive and non-competitive inhibition and how these differ.
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