Which metabolite of TCA cycle is used in detoxification of ammonia in brain_____________?
Correct answer: C. Alpha ketoglutarate
- A. Oxalocetate
- B. Ornithine
- C. Alpha ketoglutarate
- D. Glycine
Explanation
Alpha-ketoglutarate accepts amino groups to form glutamate, and glutamate then binds ammonia to form glutamine for safe transport in the brain. Ornithine belongs primarily to the urea cycle, which is not the main brain ammonia-detoxification pathway.
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