Moderate

Which enzyme will be produced in a cell if there is a nonsense mutation in the lacY gene?

Correct answer: C. β-galactosidase

  • A. Transacetylase
  • B. Lactose permease and transacetylase
  • C. β-galactosidase
  • D. Lactose permease

Explanation

A nonsense mutation stops polypeptide synthesis due to the formation of a termination or non­sense codon. In the lac operon, the sequence of structural genes is Z, Y, and A, which respectively code for b-­galactosidase, lactose permease, and transacetylase. If the gene Y has a nonsense mutation, gene expression will stop at it, resulting in non­expression of both gene Y and successive gene A. Thus, only the β-galactosidase enzyme will be produced.

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