When horse serum is injected intravenoulsy in to a rabbit and again in to the skin two or three weeks later, what is the necrotizing reaction that occurs as the site of the second injection________________?
Correct answer: C. Arthus phenomenon
- A. Atopy
- B. Anaphylaxis
- C. Arthus phenomenon
- D. Serum sickness
Explanation
The Arthus phenomenon is a local immune-complex reaction in a previously sensitised animal, causing oedema, haemorrhage and necrosis at the site of antigen injection. Generalised anaphylaxis affects the whole body, whereas serum sickness is a systemic immune-complex illness.
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