Moderate

When horse serum is injected intravenoulsy in to a rabbit and again in to the skin two or three weeks later, what is the necrotizing reaction that occurs as the site of the second injection________________?

Correct answer: C. Arthus phenomenon

  • A. Atopy
  • B. Anaphylaxis
  • C. Arthus phenomenon
  • D. Serum sickness

Explanation

The Arthus phenomenon is a local immune-complex reaction in a previously sensitised animal, causing oedema, haemorrhage and necrosis at the site of antigen injection. Generalised anaphylaxis affects the whole body, whereas serum sickness is a systemic immune-complex illness.

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