What is the principal antiparasitic action of ivermectin?

Correct answer: C. Opening glutamate-gated chloride channels

  • A. Blocking folate synthesis
  • B. Inhibiting bacterial cell-wall formation
  • C. Opening glutamate-gated chloride channels
  • D. Blocking parasite tubulin assembly

Explanation

Ivermectin increases chloride ion entry through glutamate-gated chloride channels in invertebrates, causing paralysis and death. Folate inhibition and cell-wall inhibition are mechanisms of other drug classes.

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Covers how drugs act in animals, including pharmacokinetics, pharmacodynamics, routes of administration, dosage forms, adverse effects and drug interactions. Major groups include antimicrobials, antiparasitics, analgesics, anaesthetics, anti-inflammatory drugs, hormones and cardiovascular medicines, with attention to withdrawal periods and species differences.

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