Trimethoprim is commonly combined with sulfamethoxazole because the combination produces which effect?
Correct answer: C. Sequential blockade of folate synthesis
- A. Inhibition of bacterial cell membrane formation
- B. Direct stimulation of bacterial ribosomes
- C. Sequential blockade of folate synthesis
- D. Prevention of viral nucleic acid release
Explanation
Trimethoprim and sulfonamides inhibit successive steps in bacterial folate synthesis. This sequential blockade produces stronger antibacterial activity than either drug alone in suitable infections.
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Covers how drugs act in animals, including pharmacokinetics, pharmacodynamics, routes of administration, dosage forms, adverse effects and drug interactions. Major groups include antimicrobials, antiparasitics, analgesics, anaesthetics, anti-inflammatory drugs, hormones and cardiovascular medicines, with attention to withdrawal periods and species differences.
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