The response of the body against the transplanted organ is:
Correct answer: D. Cell-mediated Response
- A. Homeostatic Response
- B. Primary Immune Response
- C. Behavioral Response
- D. Cell-mediated Response
Explanation
Transplant rejection is caused primarily by a cell-mediated immune response to HLA antigens expressed on donor antigen-presenting cells (APCs) transferred along with the transplanted organ. Recognition of donor HLA antigens on the cells of the graft induces vigorous T cell proliferation in the recipient.
This question appeared on the UHS MDCAT 2015 paper, which you can sit online with every answer explained.
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Specific defense mechanisms provide targeted immunity through B lymphocytes, T lymphocytes, antibodies and memory cells that recognize particular antigens. Questions cover humoral and cell mediated responses, clonal selection, primary and secondary immune responses, vaccination and passive immunity, while distinguishing adaptive defenses from the immediate, non specific innate response.
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