Moderate

The primary site of action of antidiuretic hormone is on the_______________?

Correct answer: A. Distal tubules and collecting ducts in the kidney

  • A. Distal tubules and collecting ducts in the kidney
  • B. Afferent arterioles of the glomeruli
  • C. Thirst center in the hypothalamus
  • D. Osmoreceptors in the hypothalamus

Explanation

ADH acts mainly on V2 receptors in the late distal tubules and collecting ducts, inserting aquaporin-2 channels and increasing water reabsorption. Its actions on hypothalamic osmoreceptors and the thirst centre regulate secretion and intake rather than being its primary renal site of action.

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