The primary cause of acantholysis in pemphigus vulgaris is___________?
Correct answer: A. auto immunity
- A. auto immunity
- B. Intercellular oedema
- C. intra epithelial oedema
- D. chronic alcoholism
Explanation
Pemphigus vulgaris is an autoimmune disease in which antibodies against desmosomal proteins, especially desmoglein 3, cause loss of keratinocyte adhesion and acantholysis. Oedema and alcoholism do not produce the primary mechanism.
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