Asked in UHS MDCAT 2017 2017Moderate

The major factor in producing hypertonic urine is:

Correct answer: D. Gradual increase in osmolarity from cortex to medullary portion.

  • A. Glomerulus.
  • B. Influence of aldosterone.
  • C. ADH influencing on collecting duct.
  • D. Gradual increase in osmolarity from cortex to medullary portion.

Explanation

The major factor in producing hypertonic urine in mammals is gradually increasing osmotic concentration from the cortex to the medulla. Juxtamedullary nephrons are specifically instrumental in the production of concentrated urine via a counter current mechanism which uses high medullary osmolarity.

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