The classical pathway of complement activation is initiated most directly by:
Correct answer: C. Antigen-bound antibody
- A. Mannose on a microbial surface
- B. Bacterial lipopolysaccharide alone
- C. Antigen-bound antibody
- D. Spontaneous C3 hydrolysis
Explanation
The classical pathway begins when C1 binds to antibody, usually IgM or IgG, attached to an antigen. Lipopolysaccharide and microbial mannose mainly activate alternative or lectin pathways.
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Covers the structure, classification, growth and transmission of bacteria, viruses, fungi and other disease causing microorganisms in animals. It explains innate and acquired immunity, antibodies, antigens, vaccination, hypersensitivity and diagnostic methods, while distinguishing infectious agents from the immune responses they produce.
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