Part of the amino acid sequences in normal and sickle cell hemoglobin are shown. Normal haemoglobin (Thr - pro - glu - glu) Sickle cell haemoglobin (thr - pro - val - glu) The mRNA codons for these amino acids are Glutamine (glu) GAA GAG, Threonine (thr) ACU ACC, Proline (pro) CCU CCC, Valine (val) GUA GUG. Which transfer RNA molecule is Involved in the formation of this part of the sickle cell haemoglobin?
Correct answer: B. CAU
- A. GUG
- B. CAU
- C. UGC
- D. GAG
Explanation
The transfer RNA has complementary base pairs to mRNA. The unique amino acid in sickle cell is valine, the mRNA codons of valine are GUG and GUA, the complementary bases are CAC and CAU (Guanine to Cytosine, Uracil to Adenine and vice versa). So option B is correct.
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