Okazaki fragments are formed in lagging strand because:
Correct answer: B. Lagging strand is 3 to 5 direction
- A. Lagging strand does not allow continuous replication
- B. Lagging strand is 3 to 5 direction
- C. Lagging strand is 5 to 3 direction
- D. Lagging strand is placed near to leading strand
Explanation
The main reason for Okazaki fragments forming on the lagging strand is the antiparallel nature of DNA strands and the requirement for DNA polymerase to synthesize DNA in the 5' to 3' direction. Because the DNA polymerase can only add nucleotides in the 5' to 3' direction, the lagging strand, which runs in the opposite direction from the replication fork, has to be synthesized discontinuously in short fragments, each of which starts with an RNA primer. These fragments are then later joined together by DNA ligase to form a continuous strand.
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