Mutation in GNAS 1 gene is associated with________________?
Correct answer: A. Fibrous dysplasia
- A. Fibrous dysplasia
- B. Ossifying fibroma
- C. Focal cementoosseous dysplasia
- D. Periapical cementoosseous dysplasia
Explanation
Fibrous dysplasia is commonly caused by postzygotic activating mutations of the GNAS gene, producing abnormal Gs-alpha signaling and replacement of normal bone by fibrous tissue. Ossifying fibroma and cemento-osseous dysplasias have different molecular associations.
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