Muscle fatigue results due to deficiency of _ and excess accumulation of _.

Correct answer: A. Adenosine triphosphate, Lactic acid

  • A. Adenosine triphosphate, Lactic acid
  • B. Adenosine triphosphate, Ionic imbalance
  • C. Glucose, Lactic acid
  • D. Glucose, Ionic imbalance

Explanation

Muscle fatigue occurs when muscles are unable to generate force or contract due to a combination of factors. The two main factors are: 1. Deficiency of Adenosine Triphosphate (ATP): ATP is the primary energy source for muscle contractions. When ATP levels are depleted, muscles cannot contract effectively, leading to fatigue. 2. Excess accumulation of Lactic Acid: During intense muscle activity, anaerobic metabolism occurs, leading to the accumulation of lactic acid. High levels of lactic acid disrupt muscle function, leading to fatigue, soreness, and stiffness.

This question appeared on the KMU MDCAT 2023 (retake) paper, which you can sit online with every answer explained.

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About Muscle Contraction

Muscle contraction is explained by the sliding filament model, in which myosin heads pull actin filaments within sarcomeres using ATP. The topic covers calcium, troponin, tropomyosin, the neuromuscular junction and relaxation, with attention to how filament length stays almost constant while the sarcomere shortens.

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