According to the sliding filament hypothesis, the release of_ from the sarcoplasmic reticulum causes the reorientation of certain components in the thin filament, permitting them to bind with extension from the thick myosin filaments:

Correct answer: B. Calcium

  • A. Sodium
  • B. Calcium
  • C. Magnesium
  • D. Potassium

Explanation

Option B is correct. According to the sliding filament hypothesis, the release of calcium ions from the sarcoplasmic reticulum causes the reorientation of certain components in the thin filament, permitting them to bind with extension from the thick myosin filaments. Calcium ions play a crucial role in muscle contraction by binding to the protein troponin on the thin filament. This binding causes tropomyosin to move out of the way, exposing myosin binding sites on the actin filament. Myosin heads can then bind to these sites, and cross-bridges can be formed. The cross-bridges then power the sliding of the thin filaments past the thick filaments, which results in muscle contraction. The other options are not involved in muscle contraction: Sodium ions are involved in nerve conduction and muscle action potentials. Magnesium ions are cofactors for many enzymes, including those involved in muscle metabolism. Potassium ions are involved in maintaining the resting membrane potential of muscle cells.

This question appeared on the KMU MDCAT 2023 paper, which you can sit online with every answer explained.

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About Muscle Contraction

Muscle contraction is explained by the sliding filament model, in which myosin heads pull actin filaments within sarcomeres using ATP. The topic covers calcium, troponin, tropomyosin, the neuromuscular junction and relaxation, with attention to how filament length stays almost constant while the sarcomere shortens.

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