Malonate inhibits succinate dehydrogenase because it resembles succinate. This is an example of
Correct answer: B. competitive inhibition
- A. non-competitive inhibition
- B. competitive inhibition
- C. feedback inhibition
- D. denaturation
Explanation
Malonate is close enough in structure to succinate to occupy the same active site without being converted, which is the definition of competitive inhibition, and it is the textbook example. The inhibition can be reversed by raising the succinate concentration. Feedback inhibition is a regulatory mechanism in which the end product of a pathway inhibits an earlier enzyme, usually allosterically.
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About Enzyme Inhibitors
Enzyme inhibitors reduce reaction rate by interfering with enzyme-substrate interaction or catalytic activity. Coverage includes reversible competitive, non-competitive and uncompetitive inhibition, the effects of inhibitor concentration on reaction rate, and why competitive inhibition can be reduced by increasing substrate concentration.
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