Liver Synthesizes:

Explanation

The liver is the central station of metabolism and consequently the body's central metabolic clearing house. Due to this characteristic, liver functions are pivotal to homeostasis and involve interaction with most of the body's organs systems. The liver supports the excretory role of the kidney by detoxifying many chemical poisons and produce ammonia, urea and uric acids from the nitrogen of amino acids. Removal of salts with water by the sweat glands and of sebum by sebaceous glands seems to be excretory in nature. The removal of water and salts from sweat glands is for the purpose of thermoregulation, and of sebum on the skin is for protection against microorganism. Therefore, in context of definition of excretion, skin may not be considered as an excretory organ. Among the various nitrogenous wastes described earlier, urea is the principal excretory product and liver form it from the waste nitrogen. The metabolic pathways involved in the production of urea are termed as urea cycle. Two ammonia and one carbon dioxide molecules are shunted into the cycle to generate one molecule of urea. One ammonia molecule combines with carbon dioxide and already available precursor from previous cycle ornithine to form citrulline, subsequently another ammonia combines to form arginine. The arginine is split by arginase to form urea and the precursor ornithine for the next cycle.