Increase in pyruvate and lactate is seen in which of the following deficiency ?
Correct answer: A. Thiamine
- A. Thiamine
- B. Pyridoxine
- C. Niacin
- D. Vitamin C
Explanation
Thiamine pyrophosphate is required by pyruvate dehydrogenase, so thiamine deficiency blocks conversion of pyruvate to acetyl-CoA. The accumulated pyruvate is consequently diverted to lactate.
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