Increase in lactate and pyruvate is seen in deficiency of_____________?
Correct answer: D. Thiamine
- A. Pyridoxin
- B. Niacin
- C. Retinotic acid
- D. Thiamine
Explanation
Thiamine pyrophosphate is required by pyruvate dehydrogenase, so its deficiency blocks pyruvate oxidation and causes accumulation of pyruvate and lactate. Niacin deficiency affects NAD-dependent reactions but does not produce this characteristic block.
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