In the study of mitosis colchicine is a chemical used to cease mitotic cell division at metaphase.The effect of this chemical on the succeeding stages is that:
Correct answer: D. Migration of chromatids to the opposite poles will not occur
- A. Chromatin will not condense
- B. The nuclear membrane will not disappear
- C. Centrioles will not move to the opposite poles
- D. Migration of chromatids to the opposite poles will not occur
Explanation
Colchicine is a chemical that disrupts the formation of the spindle fibers necessary for chromatid separation during mitosis. When added to cells undergoing mitosis, colchicine arrests cells at metaphase by preventing the spindle fibers from pulling sister chromatids apart to opposite poles during anaphase. Thus, the migration of chromatids to the opposite poles will not occur, making Option D the correct answer. The other options refer to events that occur before metaphase, so they are not impacted by the presence of colchicine.
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About Chromosomes
Chromosomes are DNA-protein structures that carry genes and become visible during cell division. Coverage includes chromatin, centromeres, sister chromatids, homologous chromosomes, chromosome number, and the distinction between diploid and haploid cells, with links to DNA replication, mitosis and meiosis.
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