In small intestine, cholera toxin acts by______________?
Correct answer: A. ADP - ribosylation of the G regulatory protein
- A. ADP - ribosylation of the G regulatory protein
- B. Inhibition of adenyl cyclase
- C. Activation of GTPase
- D. Active absorption of NaCI
Explanation
Cholera toxin ADP-ribosylates the stimulatory G protein, Gs, locking it in an active state and causing persistent adenylate cyclase activation. The resulting rise in cAMP drives chloride and water secretion into the intestinal lumen.
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