In sickle cell anemia there is substitution of_________________?
Correct answer: A. Valine for glutamic acid at the sixth position of beta chain
- A. Valine for glutamic acid at the sixth position of beta chain
- B. Phenylalanine for glutamic acid
- C. Tyrosine for valine at the 6th position at beta chain
- D. All of the above
Explanation
Sickle cell anaemia results from a missense mutation in the β-globin gene, replacing glutamic acid with valine at position 6. This produces haemoglobin S, which polymerises during deoxygenation.
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