In Niemann-Pick's disease the following substrance accumulate in CNS in excess______________?
Correct answer: A. Phosphosphingosides
- A. Phosphosphingosides
- B. Phosphoinositides
- C. Glycerophosphatides
- D. Glycerosphingosides
Explanation
Niemann-Pick disease types A and B result from sphingomyelinase deficiency, causing sphingomyelin, a phosphosphingoside, to accumulate in lysosomes including those of the CNS. The option uses an imprecise term for sphingomyelin-containing phospholipids.
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