In 1959, Koshland proposed which of the following?
Correct answer: D. Induced fit model
- A. Unit membrane model
- B. Fluid mosaic model
- C. Reflective index model
- D. Induced fit model
Explanation
In 1959, Daniel E. Koshland, an American biochemist, proposed the "induced fit" model of enzyme-substrate interaction. This model is an extension of the earlier "lock and key" model proposed by Emil Fischer. The induced fit model suggests that the active site of an enzyme is flexible and can undergo conformational changes upon binding to a substrate. In other words, the enzyme is not a rigid structure with a pre-formed active site (as implied by the lock and key model), but rather, the binding of the substrate induces changes in the enzyme's structure to achieve optimal interaction.
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About Enzymes
Enzymes are biological catalysts that lower activation energy without being consumed, and their specificity is explained by the lock and key and induced fit models. Work includes the effects of temperature, pH and substrate concentration on reaction rate, plus competitive and non-competitive inhibition and how these differ.
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