In 1956 Vernon Ingram discovered molecular basis of:
Correct answer: C. Sickle cell anemia
- A. Cancer
- B. Phenylketonuria
- C. Sickle cell anemia
- D. All
Explanation
In 1956, Vernon Ingram's discovery focused specifically on the molecular basis of sickle cell anemia. He found that a single amino acid substitution in the hemoglobin protein caused the characteristic sickling of red blood cells in individuals with the disease. This substitution involves the replacement of a glutamic acid residue with a valine residue at position 6 of the beta-globin chain. This discovery significantly advanced our understanding of the genetic basis of sickle cell disease.
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Chromosomes are DNA-protein structures that carry genes and become visible during cell division. Coverage includes chromatin, centromeres, sister chromatids, homologous chromosomes, chromosome number, and the distinction between diploid and haploid cells, with links to DNA replication, mitosis and meiosis.
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