How do local anaesthetics produce their main therapeutic effect?
Correct answer: A. They block voltage-gated sodium channels
- A. They block voltage-gated sodium channels
- B. They increase dopamine release in the brain
- C. They stimulate opioid receptors in the spinal cord
- D. They inhibit acetylcholinesterase at synapses
Explanation
Local anaesthetics block voltage-gated sodium channels and prevent action potential transmission in sensory nerves. They do not produce local pain relief by stimulating opioid receptors or increasing dopamine.
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About Analgesics and CNS Drugs
This area covers opioid and non-opioid analgesics, local anaesthetics, sedatives, anxiolytics, antidepressants, antipsychotics, antiepileptics and drugs for Parkinsonism. It examines therapeutic actions, dependence, respiratory depression, extrapyramidal effects, serotonin related toxicity and the distinction between pain relief, sedation and loss of consciousness.
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